What Is Hantavirus? CDC Monitors Outbreak After Cruise Ship Virus Killed 3

Hantavirus is a rare but life-threatening virus primarily carried by rodents that came under national attention recently after an outbreak linked to the MV Hondius cruise ship caused three deaths. 

The Centers for Disease Control and Prevention confirmed on May 6 that the U.S. State Department is leading a “coordinated, whole-of-government response” to monitor Americans who traveled on the Netherlands-based Oceanwide Expeditions vessel. 

Eight passengers have been linked to the outbreak so far, with health authorities worldwide being contacted as investigations continue into how travelers were exposed while the ship operated in the Atlantic Ocean.

The virus causes Hantavirus Pulmonary Syndrome (HPS) in the Americas, a severe respiratory disease that begins with flu-like symptoms such as fever, fatigue, muscle aches, headaches, and abdominal issues before rapidly progressing to coughing, shortness of breath, and fluid in the lungs. Symptoms typically appear one to eight weeks after exposure, and the disease carries a fatality rate of approximately 38 percent. In the United States, hantavirus does not spread person-to-person and is instead transmitted when people breathe in air contaminated with urine, droppings, or saliva from infected rodents like deer mice. Exposure often occurs while cleaning cabins, sheds, or enclosed spaces with rodent infestations, making the cruise ship cluster unusual compared to typical rural cases in western states.

There is currently no specific treatment, cure, or vaccine for hantavirus infection, and medical care focuses on supportive ICU treatment such as oxygen therapy and blood pressure management for patients with severe respiratory distress. Prevention remains the most effective defense, and the CDC recommends rodent-proofing buildings by sealing entry points, safely trapping rodents, and avoiding sweeping or vacuuming droppings. Instead, contaminated areas should be sprayed with disinfectant, soaked for five minutes, and wiped clean while wearing gloves and an N95 mask. Cabins and storage areas should also be aired out for at least 30 minutes before cleaning to reduce airborne risk.

Passengers who were recently aboard the MV Hondius are urged to monitor for symptoms for up to eight weeks after travel and contact a healthcare provider immediately if they develop fever, muscle aches, or breathing difficulties, mentioning their potential exposure. While hantavirus remains rare, the 2026 outbreak highlights the importance of awareness and early medical intervention. The situation is developing, and the CDC continues to coordinate with international health authorities to track cases and prevent further spread.