Is Fruit As Bad As Processed Sugar? - How To Burn Fat & Repair The Body | Dr. William Li

Terrific Physics
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Oct 25, 2026
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Are there particular foods that are uniquely worse for us
when it comes to fat deposition,
when it comes to the types of fats that we want
to make sure that are under control?
Yeah. Well, look, the answer is yes.
And the science tells us that the foods that encourage
the excessive growth of body fat
and that encourage inflammation and uh and um and thwart
our metabolism kind of knock our metabolism derailed
our metabolism uh are very much the
foods that are talked about as being not so good
for you sodas both regular soda and diet sodas
with artificial sweetener sodas um non-caloric sodas
um uh added sugars too much added sugar
too much calories i mean that's like basically
not not just filling up your gas tank that's like
putting a jet nozzle and jetting out that gas like
your metabolism can handle it but at a certain
point it's going to go whoa this is way too much
for me to handle over time again once or twice
occasionally not a big deal over time
that overwhelmingness of the metabolism leads to
So spillage leads to waste,
leads to toxicity, so added sugars.
Number three, ultra-processed foods.
Now, ultra-processed foods almost has become a bumper sticker,
so let me explain a little
bit more closely.
These are food products that big companies make,
but even small companies make them,
and they fundamentally take whole foods,
raw ingredients, and they transform them and combine
them in ways and extrude them
and shape them in ways in which the product doesn't even
resemble food anymore.
And so the fact of the matter is that the shape
of your breakfast cereal or some of
the candy you might eat, the combinations, that's ultra-processed.
And ultra-processed foods also tend to be cheap.
It tends to live forever or last for a long time.
And the reason it lasts, and it tastes great.
It tastes great because it's artificially
flavored, often with chemicals.
It looks beautiful because it's artificially colored.
Now, I know in Europe, for example, there's been,
I think, a faster enlightenment of protecting citizens
by banning some of the artificial flavorings and colors.
In America, in the United States of America, not so.
There's still a lot of things that are banned in Europe
that are common in the foods that are surrounding us now.
those damage our metabolism they damage
our health defenses they damage our gut microbiome which is
connected to our metabolism by helping
to streamline our metabolism um so that's ultra
processed foods anything that by the way you pick up
and it's got like 20 ingredients and you look
at them and you can't pronounce most of them
and you can't tell what they do that's something that
is important that i sort of use a shorthand
for people like teach me dr lee about what an ultra
processed food actually is, I say, look,
there's a lot to say about that. But if you pick up a
package and you read the ingredients,
just like 20 ingredients on there, and you can't define what
every ingredient does, what it contributes,
it's probably ultra processed. That's a good way to
look at it. And then I would actually say
that other things that encourage derailing of our
metabolism over it you know unhealthy oils uh
excessive saturated fats like in red meats
excessive like a little bit good source of protein um uh uh
and i would also say processed meats
uh you know because they're processed they've got all kinds
of other chemicals and things
associated with them uh
so by the way i just listed the same things that everyone talks about
over and over again that are not so good
for us what i'm saying is that now we have another reason
to understand that they actually derail our hardwired metabolism
and they encourage harmful
body fat to actually grow yeah yeah exactly i
think you know it always serves as a reminder
um to go through this and as a general heuristic
you know what you just described there if you
can't recognize the ingredients it's packaged it has
a very long shelf life it most likely has got
a lot of contaminants and a lot of additives
um the environmental pollutants that you talk about
in your book as well about how they're obesogenic you know
a lot more people are coming around to
this idea about phthalates
and other obesogens um as derailing our metabolism so that's really
important um i think we should we should go
into the good stuff now like i i want to talk about
these bioactives so you know it was enlightening
to to read about the mechanisms behind bioactives
and how they can impact, uh, healthy fat,
you know, how they can amp up, uh, your, your
brown fat, how they can trigger thermogenesis
and how they can improve your mitochondria
that, you know, the, the power cells of your,
the powerhouses of your cells.
Why don't we talk about those mechanisms first,
then perhaps we can go into some of those
bioactives and then dive into some
of those delicious foods that you and I both love.
Sure.
Okay.
so um as we discussed there are um three main types
of body fat wiggly jigglies which is the
subcutaneous fat you can see the visceral fat
which is the the choking fat of our organs wrapped
around our organs okay that you need some of it
but too much of any of those things is not good
and then the brown fat
which is to our to to the best of our knowledge it's all good stuff
all right it actually it's the space heater the fuel cell
and it and it's designed to burn down
extra energy so it's a good fat that can fight
the bad fat in fact by burning off extra fuel
why by the way i want to explain why it's called brown fat
because it has to do with the mechanism
um brown fat is is brown colored
and they've looked at this under the microscope because
brown fat contains a lot of iron it turns out
that the space heater function the the
the the cellular organelle that generates the heat is the mitochondria
and when i was in medical
school and probably you as well rupee
and we're trying to we had to memorize everything um and
there were like thousands of things
to memorize every single week um i tried to find fun ways to
memorize so i used to memorize mitochondria
as the mighty chondria you know and it's small but
mighty and these are the fuel cells
these are the nuclear power plants of our cells they generate
energy and to generate that energy there's a lot
of iron in it same kind of iron that causes rust
all right that gets rusty and so rusty iron is brown
and so mitochondria are brown and brown fat
even though it's thin
and it's wafer thin is packed with mitochondria this fuel generating
light up um stuff the organelles the nuclear power plants
and because it's so densely packed
of mitochondria mitochondria it's got a lot of iron in it
so that's why it looks brown so number
one there's a reason why brown fat looks brown yeah
um now uh the way that actually you can turn
on and get rid of harmful body fat the easiest way
is actually to activate thermogenesis basically
that's just turning flipping the switch
so that your brown fat starts to fire up um i showed you
a little lighter a torch but actually if you think about a gas stove
which most people have in their
kitchens or their homes right what do you do you turn on the the handle
and it goes click click
click, click, whoosh, right?
That's what certain foods can actually do. When you're eating certain
foods, it actually sends signals to your brown fat and it goes whoosh.
And once it goes whoosh,
just like your stove, it requires fuel to keep that flame going.
Where's it going to draw that
fuel from? It's going to draw it from your harmful fat.
So that's how you burn it down.
So that's one basic mechanism,
but it gets much more interesting than that for thermogenesis.
for example hot chili peppers
which i happen to like spicy food um but everyone knows what
happens when you eat something spicy like
a chili pepper uh pepper flakes you put on your pizza
that's a great example right in fact i have
a little sample here let me just show you
i just happen to be in front of i just have
to be in front of a desk so i can show you this stuff
oh yeah beautiful right and it comes like
and it comes off of a plant like that okay so what
happens is that when you put it in your tongue you feel
the burn the zing and what's happening
is that there's a bioactive called capsaicin it actually
is also there's another family called
capsaicinoids they're all that chemical family
and like a key that fits into a lock your tongue has
the lock it's a receptor for capsaicin it's
a capsaicin receptor there's a name for it by the
way i know i'll be giving lots of easy
to understand analogies for for your listeners
viewers. But all right, we got to dive
in and be a little bit of a scientist here. We've got a
receptor that's called TRPV1.
And it's not only all over our tongue, but it actually is in our
esophagus, in our stomach, in our guts,
all the way down to our intestines. And it's also at the
very tail end, even our rectum.
So you've heard that saying, burning on the way in and burning
on the way out. Hey, you know what?
That's because of TRPV1, the receptor. But here's the
interesting thing, the connection between body fat and thermogenesis.
Hot chili pepper on your
tongue lock the key fits into the lock
the TRPV1 receptor as soon as that happens you feel
ah it's spicy your tongue sends a text message to your brain amazingly
and it tells your brain to
do two things one is to release endorphins endorphins
are the feel-good hormones which
is why some people really are addicted
to eating spicy food ah i gotta have my i gotta have me some
more spicy food now the other thing
that not everybody has the same degree of response so
some people, it's just way too spicy.
They have too many receptors. The TRPV1 is so dense in
their tongue that even a little spice is overwhelming, okay?
But the second thing that
the capsaicin from chili peppers on the tongue can activate
with the text message to your brain,
it can release norepinephrine, okay?
Norepinephrine is a fight-or-flight hormone. So basically,
put up your dukes, all right, or run away, okay?
And what happens when you do that,
your eyes dilate, you start to sweat, right?
And you remember people eating spicy food,
they often sweat and they turn red, right?
You start breathing a little bit faster.
That's what's happening.
And the next time you eat something spicy,
I think you and I talked about this
when we were in person last year,
but this is what's amazing.
If you eat something spicy
and you just put yourself, like meditate a little bit,
go into a quiet place and pay attention to your body,
you will literally feel,
your brain, your activated brain,
your excited brain releasing norepinephrine, you'll feel it
running down the side of your neck
because the norepinephrine is going down nerves. You will
actually feel that sensation happening,
the current going down. And it goes right down to
the brown fat that's pressed around the side
of your neck to light up that flame. That's called
thermogenesis. That signal norepinephrine binds
to a receptor on the top of your brown fat. It's
called UCP1, don't worry about the names
but what that UCP1 does, another lock and key on top of
your brown fat is it then ignites your uh your burner on your stove uh
and then whoosh it goes
up and now in order to keep that flame going it's got
to draw the energy down right so that's an
example of chili peppers found in both Mediterranean cuisine
um Asian cuisine all kinds of Asian
cuisines that actually are part
of this um culinary traditions that that you know are very
much part of our humanity
and that's just one example of an ingredient and a mechanism there's
other ways mechanisms that can work as well
but i thought i would start with thermogenesis i love
that yeah yeah absolutely i mean you know i remember talking about
that and how uh and the
meditation and you know being intuitive
as to what's going on in your body um for for those of
I mean, there was also a reference to a couple of,
or lots of studies in the book about a
dose response with more chilies in the diet.
So they looked at different population
and they measured how much chili they have in
their diet every single day.
And you can definitely see a dose response
in the likelihood of them being slim as well.
So, you know, it's a mechanism that nicely fits
with some epidemiological data as well
that you've put throughout that entire book.
and clinical trials,
because I've actually taken the capsaicin out from chili peppers.
They packed them into a little uniform tablets of the same dose.
And they studied this low dose
versus high dose. And they gave an intervention for four weeks,
eight weeks, 12 weeks. And you
can kind of see the longer you give it,
the more weight you will actually lose. And so, you know,
by the way, this comes right back to something very important.
Most people who go on diets have
a singular goal which is actually to lose weight
but what we really want to do is improve our body
composition by burning down the harmful fat let's let's dive
into different categories of food now
um fruit i think fruit has got a bit
of a bad name you know everyone's sort of demonizing the
fact that it has uh natural delicious sugars
um but you know you talked about apples grapefruit
berries uh you know even tomatoes uh
as as being beneficial as part of this smorgasbord of all
these different ingredients should be that we should
be consuming why don't we dive into a
fruit of your choice and and and go into what they contain
and how they might be beneficial at
fighting fat and and and improving our metabolism
because i i think it's you know something i'm
commonly asked about like should i eat fruit is it
not you know uh is it not something that puts a
makes me put on weight all right well obviously you can see i'm
in front of a table that i've
been using for show
and tell here's one of my favorite fruits it's a pear okay and it's a
medium-sized pear and pears are very nutrient dense it's one
of my favorite fruits um they're
sweet but not too sweet they're not as sweet
as a mango they're not sweet as a pineapple
um and they've got a lot
of dietary fiber they've got six grams of dietary fiber
and pears also have a bioactive called chlorogenic acid
um chlorogenic acid is not only found in
pears it's found in apples it's found
in coffee you know mother nature is very clever she actually
puts a lot of these useful bioactives across multiple food types
but i love pears and i want
to use this one of the things that i i
a fruit i enjoy eating to address this um i think it's a
it's an extreme interpretation well intentioned about
the harms of sugar and fructose you know
i think as as people we we love to either um make
a food a hero or a villain and um it is true
sugar too much sugar not good good for you
but you know our brain depends on sugar our body can
make sugar and so it's really not fair to basically say oh
a sweet fruit is really bad um fruits are
very nutrient-dense, which is they have sugar for energy,
they have fiber, they've got microbiome,
they've got bioactives to activate our health defenses
and activate our metabolism and activate
thermogenesis as well. Here's what you want to do.
You want to actually choose foods like fruits
that taste great, that are pleasing,
that also are nutrient-dense and give you all these other
factors that are good for your body.
So net-net, you're getting some energy from the fructose and
of sugar you're getting some prebiotic stuff
from the from the dietary fiber and you're getting a
ton of these bioactives to activate
your health defense you just can't reduce everything to the
sweetness of the fruit that's ridiculous
and i think that's very important to actually
state that yeah yeah i think it's really important
and you know when i look at an apple or a pear or
berry i don't just think about you know it's got vitamin c it's got
a bit of sugar and i'm thinking
of like the hundreds if not thousands
of different polyphenols that are having unique impacts on my
body yes some of it is on uh on weight control
and you know all the things i've learned from your
books uh but you know also on angiogenesis on DNA
on our gut microbiota you're really i want people
to really think about the wider aspect
of what we're consuming on a day-to-day basis and whole
foods are just fantastic they're giving us
that that huge selection of different uh nutrients
Now, let me give you an example,
though, where we do want to be careful.
Oranges, citrus, are wonderfully delicious.
They're pretty sweet.
There's quite a lot of sugar in an orange.
So people always ask me, well, what about fruit juice?
And I tell people, you know what?
Oranges, citruses are very nutrient-dense.
They've got dietary fiber.
Anybody who's ever peeled an orange
and eaten it slice by slice knows there's a lot of dietary fiber to it.
You can see it.
You can taste it.
You can feel it.
It's also very sweet, which, you know,
is good, but too much sweetness, not so good.
And it's loaded with bioactive,
like these polyphenols, naringenin, hesperidin,
limonene, like all kinds of great stuff
that's good for your metabolism, fights body fat,
activates your health defenses.
But let's compare an orange to a glass of orange juice.
Now, I like to eat, I like, I actually like orange juice.
But, you know, if you remove all the fiber from orange,
all the pulp you're getting,
you're removing a lot of the good stuff all right
if you ultra process the orange juice like you see
in a lot of the commercial inexpensive versions you can buy
in the grocery store you might have
actually removed some of the polyphenols as well
but even if you fresh squeeze it a tall glass of
orange juice i could you know on a hot day
and i want to slake my thirst that tall glass that'll
go down my gullet i can whip it down
in 30 seconds look look look look look right okay
you know how many oranges in the sugar of orange
of those oranges that would take to make a tall
glass of orange juice on average eight oranges
now i would never sit down and eat eight oranges
at a time yeah that's an example of where you want
the all the beneficial healthful benefits
the fruits versus the juice if you choose
the juice it's a lot easier to eat a lot more of that
sugar compared to a whole fruit.
