A Red Molecule found in Multiple Foods is Implicated in Brain Health - New Studies

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0:00 - Introduction
0:31 - Lycopene and the Brain
3:55 - A Brain Tingling with Carotenoids
5:42 - Alzheimer’s, Dementia, and Problems of the Future
7:30 - Dosing & Foods

References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)]
*[Study 1081]* López-Solís R, Donat-Vargas C, Ramírez-Carrasco P, et al. Tomato intake improves cognitive performance and modulates functional brain networks in healthy adults: a randomized crossover clinical trial. Antioxidants (Basel). 2026;15(5):644. doi:10.3390/antiox15050644.

*[Study 1082]* Crowe-White KM, Nagabooshanam VA, Dudenbostel T, Locher JL, Chavers TP, Ellis AC. 100% watermelon juice as a food-first intervention to improve cognitive function: ancillary findings from a randomized controlled trial. J Nutr Gerontol Geriatr. 2021;40(4):304-312. doi:10.1080/21551197.2021.1988028.

*[Study 1083]* Wattanathorn J, Muchimapura S, Thukham-mee W, Tong-un T. Congee containing carotenoids-enriched functional ingredient from tomato improves cognition, serum α-synuclein, monoaminergic function, and gut-brain axis functions in the elderly volunteers. Life (Basel). 2025;15(7):1093. doi:10.3390/life15071093.

*[Study 1084]* Crosta F, Stefani A, Melani F, et al. Improvement of executive function after short-term administration of an antioxidants mix containing Bacopa, lycopene, astaxanthin and vitamin B12: the BLAtwelve study. Nutrients. 2021;13(1):56. doi:10.3390/nu13010056.

*[Study 1085]* Renzi-Hammond LM, Bovier ER, Fletcher LM, et al. Effects of a lutein and zeaxanthin intervention on cognitive function: a randomized, double-masked, placebo-controlled trial of younger healthy adults. Nutrients. 2017;9(11):1246. doi:10.3390/nu9111246.

*[Study 1086]* Power R, Coen RF, Beatty S, et al. Supplemental retinal carotenoids enhance memory in healthy individuals with low levels of macular pigment in a randomized, double-blind, placebo-controlled clinical trial. J Alzheimers Dis. 2018;61(3):947-961. doi:10.3233/JAD-170713.

*[Study 1087]* Lopresti AL, Smith SJ, Drummond PD. The effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported mild cognitive complaints: a randomized, double-blind, placebo-controlled study. Front Nutr. 2022;9:843512. doi:10.3389/fnut.2022.843512.

*[Study 1088]* Yuan C, Chen H, Wang Y, Schneider JA, Willett WC, Morris MC. Dietary carotenoids related to risk of incident Alzheimer dementia (AD) and brain AD neuropathology: a community-based cohort of older adults. Am J Clin Nutr. 2021;113(1):200-208. doi:10.1093/ajcn/nqaa303.

*[Study 1089]* Morris MC, Wang Y, Barnes LL, Bennett DA, Dawson-Hughes B, Booth SL. Nutrients and bioactives in green leafy vegetables and cognitive decline: prospective study. Neurology. 2018;90(3):e214-e222. doi:10.1212/WNL.0000000000004815.

*[Study 1090]* Devore EE, Kang JH, Stampfer MJ, Grodstein F. The association of antioxidants and cognition in the Nurses' Health Study. Am J Epidemiol. 2013;177(1):33-41. doi:10.1093/aje/kws202.

*[Study 1091]* Christensen K, Gleason CE, Mares JA. Dietary carotenoids and cognitive function among US adults, NHANES 2011-2014. Nutr Neurosci. 2020;23(7):554-562. doi:10.1080/1028415X.2018.1533199.

*[Study 1092]* Yuan C, Fondell E, Ascherio A, et al. Long-term intake of dietary carotenoids is positively associated with late-life subjective cognitive function in a prospective study in US women. J Nutr. 2020;150(7):1871-1879. doi:10.1093/jn/nxaa087.


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