Scientists Found It Destroys Cancer Cells… & Builds Immune System Too! I Dr. William Li
Your immune system is doing something remarkable every single day: searching your body for abnormal cells and helping eliminate them before they have the opportunity to become a problem.
But as we age, this defense system can become less effective—a process known as immunosenescence. At the same time, the immune system can become less capable of switching inflammation off, contributing to chronic low-grade inflammation known as “inflammaging.”
In this video, Dr. William Li explains the connection between aging, immunity, inflammation, cancer, brain health, and muscle loss—and reveals 3 everyday foods that can help support healthy immune function.
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Video Summary
AI Generated
This video explores immunosenescence, the age-related decline of the immune system, and its role in chronic inflammation, cancer, Alzheimer's, and muscle loss. It explains how the loss of immune regulation leads to \"inflammaging\" and provides dietary recommendations—including blueberries, green tea, and olive oil—to help balance the immune response and maintain overall health.
So your immune system is constantly identifying threats,
responding to them, and keeping the body safe and secure.
And when your immune system is not strong,
or it becomes dysregulated, or it becomes weakened,
all of those protective measures actually are compromised.
Here's what happens when you age.
The immune system can actually start to get slightly weaker.
This is a process called immunosenescence.
Senescence really means kind of slowing down, becoming less effective.
And what happens is there are two things.
Number one, there's a loss of immune defense.
So your shields are down.
Your immune system, the cells, become less and less effective at responding to threats.
And the second thing that can happen is that the immune system,
which normally is able to mount a little bit of inflammation to clean up.
Inflammation actually helps to clean up areas where your body might be compromised.
Like you have a wound, it'll actually clean up all the bacteria
and make sure everything is okay before it starts to heal.
You lose regulation when you age.
That means that even though your immune system
is able to mount a little bit of inflammation, it can't stop it.
And so immune control is actually compromised,
and now you get chronic inflammation.
In fact, they call this state of aging when your immune system's overactive.
Regulation is like your defenses are weak,
but your ability to control it are poor.
They call that inflammation, kind of a cute word,
but actually it means inflammation due to aging,
and it's coming from your immune system.
You have persistent low-grade inflammation.
That's not good because you want inflammation to be there doing its job,
then turned off right away, okay?
You don't want it to be chronic and low-grade.
That's like a smoldering fire inside the wall of a house,
like an electrical fire.
You don't want that.
You want attention to be gone when you don't need inflammation anymore.
And losing your immune regulation actually will lead to chronic inflammation,
and inflammation also has more inflammation and less immune defense protection.
I mentioned this before.
Your immune system protects you from cancer.
What most people don't realize is that your body,
which is made of 40 trillion cells or so,
have to continuously divide, reproduce the cells, right?
That's why you're still here today compared to yesterday,
why you're still gonna be here tomorrow compared to today.
Your cells are replicating, duplicating,
copying themselves over and over again throughout your lifetime.
And whenever that copying makes even the tiniest mistake,
that's a mutation, and enough mutations accumulating,
that's what leads to cancer.
On top of that, we're exposed to toxins in the environment,
environmental exposures can cause mutations,
and you can also have genetics where you're born,
you've inherited some mutations from your parents,
and when your cells are copying,
they keep copying the mistake over and over again, all right?
Now, all of these types of abnormal cells with mutations
can become a microscopic cancer.
This is a cancer you can't see, you can't feel,
won't cause any symptoms,
and most of these microscopic cancers,
microscopic tumors will never become a problem for your health.
You won't even know you're there.
This is happening in children, it's happening in adults,
it's happening in you right now.
But the reason why you're safe
and why most people never have a problem
is because your healthy immune system
is constantly conducting surveillance,
like cops on a beat, flying through your whole body,
looking for anything abnormal, like those abnormal cells.
And when it spots those cells,
it will send out signals to basically clear them out
and destroy them before those microscopic tumors
could ever stand a chance to grow.
This is happening all the time, this kind of quiet patrol.
I call your immune system an army of super soldiers,
and they're protecting you from the inside out,
wiping out all these microscopic cancers.
But as you are getting older, your immune system,
this is the, it's like the cops on the beat,
now you've got a bunch of retired police officers,
they're less nimble, they're showing up for work late,
they're actually less motivated
to actually get in the car to do the patrol.
When surveillance becomes less effective,
that's when cells that would have otherwise been eliminated
and need to be eliminated, wind up escaping detection
and they can start to grow.
When they grow up, okay, when they multiply,
that's when a tiny microscopic cancer
can become a detectable cancer,
and that detectable cancer can grow and grow and grow,
get a blood supply and explode in growth, right?
So, you know, we tell women to do a breast exam,
smallest tumor you can feel is one centimeter in size,
it's pretty small, okay?
But a one centimeter tumor
already is made up of a billion cancer cells.
So this is silent but deadly,
you really need that immune system
to wipe it out before the tumor gets that big.
And this weakening of your immune system,
immunosenescence is one of the reasons
why cancer is more common in older people, all right?
And when your immune system's weakened, not just by age,
you can really see how this problem is.
And one of the medical situations that we see this in
is after an organ transplant, right?
So let's say a liver is transplanted
or lungs are transplanted or heart's transplanted,
all right, your body, your own immune system
will reject that organ because it's not yours,
it didn't start with you,
it'll try to protect you by rejecting the organ, no good.
You wanna keep that organ,
so your doctor will actually put you
on an immunosuppressant drug, right?
This suppresses your immune system
so your body won't reject that organ.
This is actually for transplant patients.
But guess what?
When you actually suppress the immune system,
you're suppressing those super soldiers,
those cops in a beat,
they're not conducting surveillance as well
and those microscopic cancers are more likely
to take root, multiply and expand and grow, right?
That's why cancer risk is much higher
in people who have an organ transplant on immunosuppressants.
We also know,
and these are some of the amazing breakthroughs
in medical science that if you actually
boost your immune defenses,
shields up, power them up,
put more cops in the street to conduct surveillance,
all right, give them better weapons
and give them kind of night vision
to be able to look for bad guys,
guess what?
When you boost your immune system,
you can actually fight cancer.
And that's the basis for modern immunotherapy
as a treatment for cancer.
This is one of the most important breakthroughs
of cancer treatment in our lifetime
because even in older individuals,
all right, people in their 80s or even 90s,
if you give immunotherapy to boost the immune system,
that can lead to dramatic responses.
That's not chemo,
it's actually helping your body do its own thing,
your own defenses to kill that cancer,
to do what it normally is supposed to do
when you're younger,
but then it failed
and now you can restore that kind of advantage
to go tackle the cancer.
Sometimes it can actually result
in complete remissions, all right?
That's about as close to cure
as we can actually get so far
and the breakthroughs are happening
really literally every month,
we're seeing some major advances,
very, very promising, all right?
We're getting results
that we could never have even imagined
we could get before
because we figured out how to power up
the immune system.
So your immune system
is not only preventing cancer every day,
if you have cancer,
having a strong immune system
is very, very important to fight it.
So remember now,
we've talked about why the immune system
can't afford to retire,
your immune system's got to protect you
from invaders from outside of the body,
bacteria and viruses,
and protect you from invaders inside the body.
These are microscopic cancer cells.
Your immune system can't take a break ever.
Most people think about aging
in terms of wrinkles
or maybe a slower metabolism,
but your immune system
may be your most important defense
against the ravages of aging.
And if you want to understand
how your body actually protects you
as you get older,
make sure you've subscribed
to my YouTube channel
by hitting the subscribe button.
This is where I actually
break down the science of health
and give you practical tips
on what you can actually do
to improve your health.
Okay, let's look at another
immune connection,
this time in the brain
with Alzheimer's disease.
Your immune system also plays
an important role in brain health.
And here's something
that you might find surprising.
Your brain has its own immune cells.
In the brain,
those immune cells are called microglia,
G-L-I-A, microglia.
And one of the things
those microglia do,
they monitor the brain environment.
Okay, they're conducting surveillance
or checking things out
and they clear out damaged cells.
They remove debris.
Inside our body,
our cells are always getting older
or getting damaged
and need to be cleared out.
That's what microglia does.
They clear out old damaged brain cells.
And microglia help to maintain
healthy nerve function,
kind of like maintaining
the electrical system in your house, right?
You want the current to be flowing
so that your light switch
is connected to your fuse box
and everything that's electricity
dependent is actually working.
So your microglia,
your brain's immune cells
help maintain brain function.
So what happens with aging?
With aging,
your microglia immune cells in your brain
can start to falter and fail.
And one of the ways that they fail
is they can basically
become persistently activated, right?
So think about these cells.
They are there to actually help
to balance your immune defenses.
They get activated when they need to.
They turn down
when they are done with things.
But when you are aging,
that regulation,
the control of turning on
and turning off is broken.
It's like a switch
that doesn't work very well.
And when your microglia
are persistently activated,
they're on all the time.
You know what that produces?
That produces brain inflammation, all right?
And at the same time,
not only do you have more inflammation,
but the microglia,
the brain immune cells
become less effective
at clearing out the debris
or clearing out toxins, cellular debris.
So you wind up having
this double barrel problem,
too much brain inflammation
and not enough ability
to be able to clear out the toxins.
And that is something
that we start seeing
in the brains of people
with Alzheimer's disease,
as well as some other forms
of dementia as well.
This is actually an area
that is undergoing
intense investigation.
But what we do know
is that there is an immune
link to Alzheimer's disease
and it's a disruption
in the immune regulation
that is what we believe
is partly at work
to cause that brain damage.
OK, this is just another example
of an aging condition
where your immune system
isn't doing its job the right way.
Speaking of another
condition of aging,
let's talk about a condition
called sarcopenia.
This is another place
that you often see
in people who are older,
very old, they lose muscle mass.
They're kind of skinny
and shrunken, shriveled.
And there's also a role
of an aging immune system
when you lose muscle mass.
All right.
Loss of muscle mass
is called sarcopenia.
And it's not just about
not exercising enough
and not getting enough nutrition.
It turns out that
an aging immune system
also plays a role
in controlling your muscle mass.
A healthy, strong immune system
helps you build muscle,
get rid of old muscle,
build new muscle.
All right.
And that's really, really important
because even if you have
optimal nutrition,
which a lot of older people don't,
but even if you had
optimal nutrition,
you still need to be able
to go out with the old,
in with the new,
remove all the debris
and build new muscle.
Now, this is happening
all the time,
whether you exercise or not,
out with the old,
in with the new
is something that your immune system
is involved with.
Now, in muscle,
you've got special immune cells
called the macrophage,
and they are in charge of cleanup
and rebuilding your muscle.
When cleanups needed,
the macrophages are in one gear,
special gear in cleanup mode.
When a cleanup is done,
they shift gears
and they go into
repair regeneration mode.
So here's one immune cell
that can do two things
depending on what's needed.
But with aging,
immunoaging,
immunosenescence,
your macrophages
and your muscle
don't do their job as well.
And so the cleanup
doesn't happen as well.
And the rebuild
doesn't happen as well also.
And that's what we see
with immunosenescence,
one of the hallmarks of aging.
Muscle breakdown
and buildup system
is out of balance.
So you have more muscle broken down
and less sufficient muscle rebuilding.
And over the course
of weeks to months,
month after month
and year after year,
you can start to see
you start to lose muscle mass,
even if you're physically active
and even if you're
getting enough protein
and eating proper nutrition,
you still need to be able
to manage this.
And that's the link
of the immune system.
Loss of muscle mass,
loss of strength,
and that begins to make you
more vulnerable to falls.
You might lose independence.
And this is what we're
actually seeing in people
who are getting really frail
as they get older.
So sarcopenia,
loss of muscle mass
is actually pretty complicated.
You've got aging,
you've got poor diet,
you've got not enough exercise,
but you also have a problem
with the immune system as well.
OK, so let's get to the good part.
What can you do about all this?
How can you support
your immune system
during healthy aging?
Well, the good news
is that your immune system
is highly influenced
by your daily environment,
your lifestyle,
exercise, sleep, stress management,
and also what you eat.
So I want to tell you
about three foods
that can help support
your immune system at any age.
But especially as you get older,
I want you to keep these in mind.
The first food is blueberries.
Blueberries contain
natural substances.
We call them bioactives.
And then blueberries,
they're called anthocyanins,
A-N-T-H-O-C-Y-A-N-I-N-S.
Anthocyanins support
immune cell function
that can help regulate
inflammatory signaling.
Remember I told you
immune system turns on
inflammation and turns it off.
Anthocyanins can help
that function better.
They don't just activate
the immune system.
They help the immune system
function properly
with the right type of balance.
How many blueberries
do you need to eat?
Just about a cup's worth regularly.
You can eat them fresh.
You can eat them frozen.
It's an easy way to support
your immune balance.
So obviously you need to make sure
there aren't any warnings
about produce
that might be out there.
But blueberries are really good.
Green tea,
one of my favorite beverages.
Green tea has a bioactive
polyphenols called catechins,
especially something called EGCG.
That's epigallocatechin-3-gallate.
And EGCG, these catechins
support immune cells
called T cells.
T as in Thomas.
And they actually are involved
with immune signaling
and immune regulation.
And green tea also contributes
to an antiviral defense.
So drinking green tea regularly,
how much?
Two to three cups a day
actually supports
your immune system
as you age in a healthy way.
Next up, extra virgin olive oil, EVOO.
One of my favorite oils.
It's a healthy oil,
contains bioactives,
polyphenols like hydroxytyrosol
and oleocanthal.
These are anti-inflammatory
compounds that are naturally
found in olives.
So when you press out the oil,
extra virgin,
they're actually present
in the olive oil.
Now, what do these
anti-inflammatory compounds do?
They help to resolve inflammation.
Remember I told you
persistent inflammation is no good.
Chronic inflammation.
These actually start to
turn the volume back down
on inflammation,
back towards normal.
So remember, a little bit
of inflammation is good.
You don't want a lot of it
and you don't want it chronically.
But olive oil has these
anti-inflammatory polyphenols
that can actually help you
restore immune balance.
So just use extra virgin olive oil
as your primary fat
whenever you're cooking.
Or if you feel like it,
you can actually have
a few tablespoons a day,
even as a shot of olive oil.
If you found this video
interesting and useful,
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who can benefit from understanding
what happens to their immune system
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