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Super agers—from their cellular makeup to their daily habits and states of mind—are living studies in what it takes to live longer and healthier.
Biologically, they preserve better gray matter volume in their brains. Behaviorally, they tend to exercise, eat well, and avoid smoking and drinking to excess.
But what, at a deeper level, defines the formula for living the longest life possible?
Dr. Dayan Goodenowe identifies how we adapt to our changing environments—from the cellular to the behavioral level—as the prime determinant of how well we age.
Dr. Goodenowe has spent decades researching the biochemistry of neurological disorders, including Alzheimer’s disease, ALS, and autism.
How well we adapt, he says, comes down to the interplay between our purpose and our function. And this dynamic is inherent at all levels of our being. For example, at the societal level, a person adapts the teaching skills required to fulfill the purpose of being a teacher; at the cellular level, a cell adapts the motor-neuron function required to fulfill the purpose of moving our feet.
However, in the example of motor-neuron disease (amyotrophic lateral sclerosis—ALS) this interplay is compromised by a lack of “raw material” to maintain the function of foot movement.
The “raw materials” are the requisite nutrients, says Dr. Goodenowe.
As such, restoring function to patients suffering from or at risk of developing ALS, Alzheimer’s disease, and other neurological disorders is a matter of supplying the materials—in the form of targeted nutrition—that are needed.
On Vital Signs with Brendon Fallon, Dr. Goodenowe reveals changes in his own brain over 18 months of targeted nutrition—changes that challenge the idea that brain health and function are destined to decline with age.
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Super Agers: From Their Cells to Their Psychology, They Show Us How to Live to 100 and Beyond | CLIP | Vital Signs
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© All Rights Reserved.
a super Ager is generally defined as
someone over 80 who displays the mental
ability of someone decades younger an
octogenarian with the memory of someone
in their 60s 50s or even younger is a
classic example of super aging the
research shows factors like regular
exercise healthy diet and having a
strong friend and family ties go hand
inand with super aging today though
we're going to take the concept of super
aging to a deeper level with expert in
the biochemical me mechanisms of health
and disease Dr Dane G now you know
obviously eat better obviously ex
exercise for you want your circulatory
system and oxygenation of the body
proper we need to do all those things
for sure but if we want to have super
aging we need to strategically add
things back in that we know become
deficient which specific nutrient
deficiency could mean the difference
between living to 70 and living to 100
what Chief characteristic going from
ourselves to our behaviors fundamentally
determines lifespan and which everyday
activity if Done Right is equivalent to
a resistance training workout for the
brain it's an actual physical process of
the human brain and that is maintained
in super agors better than others and
it's linked to increased cortical
volumes and certain thicknesses of
certain areas of the brain welcome to
Vital Signs where we learn how to get
healthier from all angles from the
biochemical and nutritional to the
things we do that nourish our minds and
our Souls I'm brandan
Fallon over several decades Dr ganau has
issued patents conducted clinical trials
and published literature on a range of
neurological disorders including
Alzheimer's disease ALS and autism links
to his related research and his book
breaking Alzheimer's are in the
description below there are different
concepts around aging some people think
of it as a disease I'm interested for
your insights Dr goodan now how do you
see Aging in the context of the neurobi
chemical research that you've done when
people look at aging we've been kind of
programmed into looking at it like
something that it happens to us and so
like a infection or a disease and then
which has actually been the main reasons
why we die right we get in an accident
we get infected by a bad virus or we do
you know something kills us early in our
life and so that's been the primary
cause of human death for most of our
existence and so the average lifespan
for individuals was typically in the 30s
to 40s for most of you know so people
would live longer but that would be
relatively small proportion of the
population and so a lot of research has
been focused on how to prevent death
right so and we've done a very good job
of that so the average lifespan of
humans is increased dramatically over
the past hundred some years so now that
average lifespan has gone from in the
30s to 40s to in the mid 80s and it's
kind of plateaued we've done very little
successful aging beyond that but was
interesting when we look at how good
we've been at reducing what I call
premature death is that we've been very
unsuccessful at increasing our maximum
lifespan or or increasing the length of
our health and vitality and so when you
think about aging though what you're
really thinking about is the progression
to death and so really the question now
becomes is really not what is aging but
what is death and we think about life
and death as a progression but it's
really one thing and the other part
about aging and the trying to prevent
your death or try to sustain your life
for the longest time possible with the
largest amount of Vitality in it what
we're really talking about is a loss of
life and I think a lot of people forget
about we think that the absence of
something is something okay if we go
back to just basic physics for example
when people think about oh my house gets
cold or my house gets hot well there's
actually no such thing as cold cold is
actually not a phenomenon that actually
exists you either have heat or you have
a lack of heat so heat either comes into
your house or heat leaves your house but
cold does not actually come in or out
and the same concept is with life like
you can't really have there's no such
thing as death you don't actually
acquire death you lose life and so death
is the absence of life and so once we're
born once that spark of life has been
initiated it is basically on okay and it
doesn't go off until we die and that
spark of Life of function of purpose
permeates our daily living but it also
permeates every single cell of our body
and so as we look at this loss of life
or the loss of our ability to function
it comes through the first and second
laws of thermodynamics really the first
law is nature you know molecules or
atoms or matter cannot be created or
destroyed we just kind of move things
around right this is like energy
transferring from one form to another
like kinetic energy transferring to to
heat energy correct something like that
that's exactly it so for instance
photosynthesis when the Sun Shines on a
plant and it it interacts with the
chloroplast and it converts carbon
dioxide and water into glucose what it's
doing is it's not creating glucose it is
taking the carbon atoms from carbon
dioxide and the oxygen molecules from
atoms from water and it's Bing them into
creating a molecule called glucose so
everything that comes into your body
must come out so ultimately speaking
life is a balance sheet it's like an
accounting the two sides of ledgers will
always balance now we may not always
like how they balance but they will
always balance and so ultimately ashes
the ashes dust to dust ultimately the
body will Decay degenerate will
evaporate Into Thin Air so those
molecules just get transformed the
second law of third Dynamics is the law
of entropy which is all systems tend to
reach a state of disorder right it's
like the world hates order and I usually
tell the analogy of you know making your
bed in the morning like the entire world
hates a made bed that everything
conspires to unmake your bed you get up
in the morning you make your bed it's
beautiful looking then you put your
clothes on it and it starts to get
wrinkled or you sit on the edge of the
bed and it gets wrinkled and so but
you're always constantly applying energy
back to your bed so you physically have
to go and smooth the bed out so you're
applying energy to maintain that order
and at a very simple level everything in
your body is that way okay in order to
maintain the order of the human body we
are constantly applying energy into that
body to do that the uninterrupted state
of things is chaos it's it's only with
with intervention that things have order
exactly and so we and we have to add
heat we have to add energy in so our
bodies burn like we take carbon we take
hydrocarbons and we burn them into
carbon dioxide and water and that energy
that heat energy
we use that energy to maintain the
structural order of our bodies as you
can imagine our body is much more
complex than making your bed every day
and so all these systems of your body
over time become harder and harder to
maintain so aging itself like is not a
disease it's entropy and this is where
as you start looking into the underlying
causation of decline it really comes
down to some basic concepts of function
and purpose and the ability to create
and maintain order in the systems that
we have that's the opposite of of
entropy right entropy is is like chaos
like the of the body the the physiology
falling into disorder correct we have to
maintain order and so this is where the
complexity comes in of the human body
it's complex in its enormity but it's
simple in terms of its individual Parts
themselves right and so the heart has a
function the lung has a function the
cell within a heart has a function the
cell within a lung has a function and so
over long periods of time these the
ability to actually maintain this
becomes harder and harder to do like any
complex system what people forget about
the aging process is that this interplay
between our function and our purpose so
at the end of the day you need that
underlying purpose and your your body
will then match the function for that
the whole concept of healthy aging is
adaptability whole concept of life is
the ability to adapt to a changing
environment whether it's internal or
external that's gives us our Vitality
okay and so our ability to adapt to a
changing environment is 100% of our
aging process and you adapt to the
environment around you so you become a
school teacher or you become a
mathematician or you have a very
different skill set you adapt to the
skills required of your system and this
happens at even at the cellular level
because every single cell of your body
has the same DNA your heart cell has the
same DNA as your brain cell same DNA as
a fat cell but all of these cells have
different purposes okay and then they
have adapted to the purpose that they
have to fulfill and we forget things
that we think are stressful and bad for
us in our life oh it was you know
stressful going through school it's
stressful trying to get a job it's
stressful trying to find a you know a
spouse and compete and raise a family
but all of these things have time
constraints to us right and they provide
purpose they have a reason for us to get
up in the morning reason for us to
exercise and so on so when you take a
look at these super aers right and you
look at their their lives and their
structure most of them will have very
positive social relationships a big
factor in superaging populations is that
they maintain a positive social
relationship mindset um people are
important to them their relationships
are important to them because humans are
social okay we find purpose in the
people around us we find purpose in
helping others we find purpose in being
useful to others and those things of
purpose give us a reason to get up in
the morning give us a reason to eat
better meals give us a reason to be
healthy because if I want to help
someone else okay I have to be healthy
myself and psychologically and
subconsciously these things drive a lot
of our Behavior because it does drive us
to more positive behaviors versus more
negative
behaviors