[快步走] 大型基因研究证实了快走和延缓衰老之间的联系 Large genetic study confirms link between brisk walking and slower aging

大型基因研究证实了快走和延缓衰老之间的联系
研究继续表明，更积极的生活方式可以对抗衰老的一些影响，其中包括心脏损伤、记忆丧失和认知障碍。一项详细阐述了步行速度和生物年龄之间关系的新研究为这一知识宝库增添了新的内容。该研究使用了大量的基因数据，其表明那些走得更快的人可能受益于更长的健康寿命。

2019年，一项研究探讨了步态速度和健康之间的联系，其证明了40多岁时走得更慢跟加速衰老的生物指标之间的关系。另外，莱斯特大学的研究人员此前曾表明，每天只需快走10分钟可以使人的预期寿命延长3年。这些科学家现在已经利用基因数据来证实他们所说的因果关系。

这项研究的论文第一Tom Yates表示：“虽然我们之前已经表明，步行速度是健康状况的一个强有力的预测指标，但我们还不能确定快走速度真的能带来更好的健康。在这项研究中，我们使用了人类基因图谱中的信息以表明步行速度越快确实可能导致更年轻的生物学年龄，这是通过端粒测量得出的。”

据悉，端粒是位于染色体末端的帽子，可以保护染色体免受损伤，因此端粒是许多研究衰老影响的中心。当我们的细胞发生分裂时，端粒会变短并最终阻止细胞进一步分裂，这将使它们变成所谓的衰老细胞。因此，端粒长度被认为是测量生物年龄的一个有用的标记。

这项新研究分析了从英国生物银行(UK Biobank)获取的40多万名中年人的基因数据，另外它还将其与参与者自我报告的步行速度信息和参与者佩戴的运动追踪器获取的信息进行了比较。这项研究被认为是第一次将这些因素放在一起进行研究，另外，在这样做的过程中还建立了快速行走跟较年轻的生理年龄之间的明确联系。科学家们在他们的研究论文中写道，根据端粒长度，快走者和慢走者之间的差异是16年。

该研究的论文第一作则Paddy Dempsey博士指出：“这表明，习惯较慢的步行速度是识别更容易患慢性疾病或不健康老化的人的一种简单方法，而活动强度可能在优化干预措施中发挥重要作用。”

Large genetic study confirms link between brisk walking and slower aging
Research continues to show that a more active lifestyle can combat some of the effects of aging, including heart damage, memory loss, and cognitive impairment. A new study detailing the relationship between walking speed and biological age adds to this treasure trove of knowledge. The study, which used a wealth of genetic data, suggests that those who walk faster may benefit from a longer healthy lifespan.

In 2019, a study that explored the link between gait speed and health demonstrated a relationship between walking slower in your 40s and biomarkers of accelerated aging. Separately, researchers at the University of Leicester have previously shown that just 10 minutes of brisk walking a day can increase life expectancy by three years. These scientists have now used genetic data to confirm what they say is cause and effect.

Tom Yates, lead author of the study, said: "While we've previously shown that walking speed is a strong predictor of fitness, we haven't been able to say for sure that faster walking speeds actually lead to better health." In this study, we used information from the human genetic map to show that faster walking may indeed lead to a younger biological age, as measured by telomeres."

Telomeres are the caps at the ends of chromosomes that protect chromosomes from damage, so telomeres are at the center of much research into the effects of aging. When our cells divide, telomeres shorten and ultimately stop the cells from dividing further, which turns them into so-called senescent cells. Therefore, telomere length is considered a useful marker for measuring biological age.

The new study analysed genetic data from more than 400,000 middle-aged people obtained from the UK Biobank, in addition to participants' self-reported walking speed information and exercise trackers worn by participants. information was compared. The study is believed to be the first to examine these factors together, and in doing so establishes a clear link between fast walking and younger biological age. The difference between fast and slow walkers, based on telomere length, was 16 years, the scientists wrote in their research paper.

Dr Paddy Dempsey, the first author of the study's paper, said: "This suggests that accustomed to slower walking speeds is an easy way to identify people who are more likely to develop chronic disease or unhealthy ageing, and that activity intensity may play a role in optimizing interventions. Play an important role."