Early Signs Of Folate Deficiency

Vitamin B9, also known as folic acid, is an essential micronutrient required for DNA synthesis, cell division, red blood cell maturation, and fetal neural tube development. Here are five early signs of folate deficiency and why they occur. Number one, fatigue and weakness. Impaired DNA synthesis in red blood cells causes megaloblastic anemia, which leads to reduced oxygen-carrying capacity in blood and consequently, fatigue and weakness. Number two, pallor. Reduced hemoglobin levels can make the skin and conjunctiva appear pale. Number three, mouth ulcers. Rapidly dividing oral mucosal cells are particularly vulnerable to impaired DNA synthesis, resulting in mucosal damage and ulceration. Number four, a red, sore tongue, also called glossitis. Folate is necessary for rapid cell turnover. Deficiency disrupts the renewal of cells lining the tongue, causing inflammation and a smooth, painful appearance. Number five, palpitations. The heart might beat faster to compensate for reduced oxygen delivery caused by anemia.