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Too Tired to Sleep: Why Exhaustion Prevents Sleep | Fall Asleep To Science
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Aug 30, 2026
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Chapters
Transcript
0:00
Welcome to psychology for sleep
2:01
The paradox of tired wired syndrome
6:50
The exhaustion arousal cycle and neurochemical confusion
12:06
Default mode network disruption and intrusive thoughts
18:26
Circadian rhythm misalignment and the sleep pressure paradox
24:02
Amygdala hyperreactivity and the emotional vulnerability of exhaustion
31:09
Muscle tension, temperature regulation, and the reticular activating system
38:12
The brain's blood flow patterns and thalamic filtering failure
47:11
Interoception, sleep-onset dreams, and the locus coeruleus paradox
53:27
Glucose metabolism, orexin, and the metabolic trap of sleep initiation
58:57
Micro-arousals, parasympathetic failure, and the self-reinforcing cycle
1:04:50
Cortisol, melatonin, GABA, and histamine: the chemical contradictions
1:11:26
Serotonin, dopamine, adenosine receptors, and inflammatory cytokines
1:13:48
Neuropeptide Y, acetylcholine, and the loss of orchestrated timing
1:16:49
Endorphins, oxytocin, galanin, and the systems-level desynchronization
1:20:54
Contextual conditioning and the bedroom as a site of vigilance
1:24:02
Sleep effort as a self-perpetuating problem
1:27:58
Cognitive fusion and the identity of sleeplessness
1:31:09
The physiology of catastrophic thinking about sleep
1:34:59
Hyperarousal and the self-perpetuating cycle of exhaustion
1:38:12
Emotional regulation and attentional control in exhausted wakefulness
1:42:55
Social cognition and isolation in chronic sleeplessness
1:47:11
The complex systems failure of exhausted wakefulness
1:50:41
Somatic patterns and the body's role in maintaining arousal
1:53:27
Chronotype mismatch and the impact of circadian disruption
1:58:57
The role of dreams, nervous system regulation, and meaning-making
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