Doctor Reviews: Metabolic Bone Disease of Prematurity | Part 1
Metabolic bone disease of prematurity (Osteopenia or Rickets of Prematurity) can be confusing; calcium, phosphorus, vitamin D, PTH, magnesium, bone mineralization, and multiple lab values all play a role.
In this video, Dr. Tala breaks down metabolic bone disease of prematurity in a simple, clinically focused way, explaining what causes it, which premature infants are most at risk, and how calcium, phosphorus, vitamin D, PTH, and magnesium work together.
This is Part 1. In the next video, we'll cover the diagnosis and management of metabolic bone disease of prematurity.
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'Osteopenia of Prematurity' or 'Rickets of Prematurity' or Metabolic Bone Disease all refer to the same process: premature babies developing weak bones because it's so hard to feed a baby enough calcium and phosphorous. Watch this video to learn about the risk factors, the causes and the general incidence of MBD.
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Dr. Tala is a board-certified neonatologist and has worked in busy level III and IV units for the past 18 years. She has won multiple teaching awards throughout her time as a neonatologist.
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References:
Biology of Vitamin D - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/The-interactions-and-pathways-for-generating-vitamin-D-25OHD-and-1-25OH-2-D_fig2_354010148
Chinoy A, Mughal MZ, Padidela R. Metabolic bone disease of prematurity: causes, recognition, prevention, treatment and long-term consequences. Arch Dis Child Fetal Neonatal Ed. 2019 Sep;104(5):F560-F566. doi: 10.1136/archdischild-2018-316330. Epub 2019 May 11. PMID: 31079069.
Stacy E. Rustico, Andrew C. Calabria, Samuel J. Garber, Metabolic bone disease of prematurity, Journal of Clinical & Translational Endocrinology, Volume 1, Issue 3, 2014, Pages 85-91,ISSN 2214-6237, https://doi.org/10.1016/j.jcte.2014.06.004.
Endocrine Diseases of Newborn: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome “Current Insights Into Disorders of Calcium and Phosphate in the Newborn” - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Factors-contributing-to-Metabolic-Bone-Disease-of-Prematurity_tbl2_349083519
Vitamin D metabolized in liver and kidneys: https://www.empirical.health/blog/vitamin-d-is-a-hormone/
Vitamin D, Calcium, Parathyroid Hormone, and Sex Steroids in Bone Health and Effects of Aging - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Effect-of-calcitriol-on-serum-calcium-level-Calcitriol-the-active-form-of-vitamin-D_fig4_342275484
Magnesium and Bone: https://alkalineforlife.com/blogs/news/magnesium-and-its-many-roles-in-bone-health?srsltid=AfmBOooHKe7_GbaXeSF4ZhTNVsWiDLaSoXe-oSiGJTJ3VwX48bG68JkX
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***TIMESTAMPS***
00:00 – Introduction
01:40 – Definition: What Is Metabolic Bone Disease?
05:07 – Risk factors
11:46 – Pathophysiology
17:35 – Final message
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*Disclaimer*: This video is intended for educational purposes only, and while we strive to give the most accurate information, errors may occur. Subsequently, this video should not be a replacement for medical advice.
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