In this video, Dr. Doug Lucas discusses Lactoferrin, a naturally occurring protein found in the milk of mammals, including humans. It has various health benefits, including antibacterial and antiviral properties, regulation of iron absorption and metabolism, anti-inflammatory effects, and improvement of immune function and gut health. Lactoferrin has been shown to be particularly effective in promoting bone health by stimulating bone formation and suppressing bone resorption. Human studies have demonstrated positive effects on inflammation and bone turnover markers!
Study Links:
https://pubmed.ncbi.nlm.nih.gov/37680888/
https://pubmed.ncbi.nlm.nih.gov/20473630/
https://pubmed.ncbi.nlm.nih.gov/19172341/
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ABOUT DR. DOUG LUCAS
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Dr. Doug Lucas: Owner/founder of Optimal Bone Health and Optimal Human Health. My team and I work together to create custom bone optimization plans for individuals based around supplements, hormone optimization, peptides and more in order to increase bone health and longevity!
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Watch and Enjoy! Dr. Doug Lucas Key Moments in this Episode =========================
Chapters
00:00 Introduction to Lactoferrin and its Benefits
01:21 The Antibacterial and Antiviral Properties of Lactoferrin
08:03 Recommended Doses and Sources of Lactoferrin
are you looking to optimize your
supplements for bone health today I'm
going to discuss a new product that
we've added to our list of frequently
suggested supplements this one's called
lacto Farin we're going to review the
available literature and discuss my own
experience clinically that really pushed
us to make this switch if you've had a
good or bad experience with lacto faren
we'd love to hear about it please leave
it in the comments on YouTube all right
so I'm going to give you the full recipe
for how we use this product including
the dose and the brand now I have no
Financial relationship with this product
so this is purely just evidence-based
information before I do let me give you
a little bit of background so many of
you probably have not heard of lacto
Farin lactoferrin is a naturally
occurring protein that is found in the
milk of most mammals including humans
it's also particularly abundant in the
early milk after a mammal gives birth
called colostrum and that is not a
coincidence so while lactoferrin is
present in cow in Goat in sheep milk and
in human milk it is not present in
anything that's been pasteurized so the
protein gets broken down in the heating
and the pasteurization process so
lactoferrin is only available in raw
milk if someone has access to raw milk
so lactoferrin when you read about this
you'll find that lactoferrin is thought
to be antibacterial it's antiviral it
helps to regulate iron absorption it
helps to regulate iron metabolism it's
anti-inflammatory it improves immune
function it improves gut health it's
kind of like a Panacea now whenever
anything is sold as a Panacea I raise a
red flag and I say show me the evidence
what's really compelling is that there
is quite a bit of evidence for
lactoferrin I'm not going to review it
all but what I do see is that there's a
lot of evidence for lactoferrin on bone
health and that's what I really want to
review today I got introduced to
lactoferrin through a product called
milk basic protein or MBP and in that
video we discussed that MBP as an
intervention has been studied and it
does inre bone mineral density on its
own and half of MBP by volume is lacto
Farin the other half is lactoperoxidase
so before I get to the dosing and the
products let me tell you a little bit
about why I think lacto Farin is
probably better than MBP alone okay so
let's get into the studies that actually
show that lactoferrin is a really
compelling product to use for bone
health so this first one I'm going to
show here this is a 2023 review paper
and it's specifically looking at
lactoferrin as a target for future
Therapeutics so you see this kind of
research when a company or an industry
in general is looking at a product as
something that they can potentially
patent and you know potentially make a
drug out of so you see these kind of
like blanket approaches looking at all
the available literature what they found
here is that lactoferrin regulates
function of osteoblasts so those are the
cells that make bone condra sites those
are the cells that make cartilage and
also that can turn into part of the
Matrix and then osteoclasts so
osteoclasts are the cells that break
down tum bone and then mesenchimal stem
cells and stem cells are the things that
can become other things like osteoblast
and osteoclast although from different
cell lines the paper discusses all the
detailed mechanisms and I won't bore you
with that but what's interesting is that
they are the same as some of the
pharmaceutical mechanisms that are out
there now what's really cool about
lactoferrin is that like most natural
products it works on both sides of the
equation so a lot of the pharmaceutical
approaches are going to work simply on
one side in fact they all work pretty
much on one side meaning that the
anti-resorptive drugs will work on the
osteoclast side the the anabolic drugs
work on the osteoblast side but natural
products tend to work on both so lacto
Farin will work on both osteoclast and
osteoblast it's kind of cool the
conclusion of this study says that
lactoferrin can rescue disregulated bone
remodeling and osteoporotic conditions
by stimulating bone formation and
suppressing bone resorption that's a
pretty powerful statement because we
don't see drugs that can do that and so
if there were a drug that could do both
and improve bone metabolism overall it
would be a showstopper of a
pharmaceutical and then I looked at all
the animal research that supported
basically coming out of that one review
paper so I'm just going to point these
out so the 2 3D fourth fifth 6th 7th and
eth studies that we reviewed these are
all animal studies but what's cool is
that they all showed benefits in an
animal model so before I get into the
human studies because there are some
human studies just a quick reminder that
if you haven't gone through our Master
Class already and you're struggling to
try to figure out what is the right
combination of stuff for you what's the
right approach to help you to improve
your bone health and potentially reverse
your osteoprosis consider our Master
Class the master class is totally free
if you're on YouTube look for the link
in the description below and it is our
opportunity to talk to you about how we
go through building an osteoprosis
program and we'll talk about all the
updates to our program and we'll have
some time for Q&A all right so what
about the human studies so the human
studies actually look
pretty good and there's some issues that
I'll talk about but in 2010 there were
two studies that were published and
these were on our population of Interest
we'll say it that way so this was a
study that looked at 38 postmenopausal
women and they were looking at
lactoferrin specifically for information
in bone health for six months so that's
pretty awesome now what I don't like
about this study is that they chose to
use a a combination of ribonuclease and
lactoferrin and so what does that mean
ribonuclease is something you can attach
to something and so they used a ribo
enrich lacto Farin why would they do
that because that is a unique molecule
and a unique molecule can be patented so
clearly this is again this is a a
company looking to produce something
that they could then patent and
obviously make money on that's how the
industry works so we have to take this a
little bit for what it is but this
ribonucleic enrich lacto Farin at 225
milligrams a day they Ed that as an
intervention Plus calcium and then the
placebo group had just calcium what they
noticed is the inflammatory markers
changed in the correct direction in both
sides meaning that the pro-inflammatory
markers went down and the
anti-inflammatory markers went up and
there's markers that you can measure for
both of those which is pretty cool they
also noticed this thing called rank
Lagan which you've heard me talk about
in reference to some drugs rank Lian
went down which is what you see with the
drug and then also CRP which is a marker
for inflammation also went down so can
we say that this ribonuclease enrich
lactoferrin is the same thing as
lactoferrin not it's not can we say that
the effect is coming from the
lactoferrin or the Rabon nucleus we
can't but it is certainly pushing Us in
the direction to say that there is
probably something relevant here what's
also good about the study though is that
it starts to give us a dose like all the
animal studies are going to use doses
all over the map and how do you relate
that to a human but these are human
studies and we're using a clear dose and
we can pull out a number from there
which I'll show you in a minute all
right so then the next study is also
from the same group I would assume it's
from the same group because it's 38
postmenopausal women using ribon nucleus
and R lactoferrin so probably the same
study group but anyway they were looking
at bone turnover markers specifically
and they did you know dosage for 6
months so what they found is that there
was indeed decreased bone breakdown and
increased bone building so again it's
working on both sides of the equation
which we really like so those are the
only two human studies we could find now
is that enough human studies to use it
well I think the answer is yes and
here's why because lacto Farin occurs
naturally I mentioned earlier that you
find it in raw dairy and we know that
raw dairy has a very different impact
than does pasteurized Dairy one of the
reasons to consume raw dairy if you can
find it and and deem it to be coming
from a safe source so lacto Farin is in
colostrum it's in raw dairy and it's
available as an over-the-counter
supplement so let's assume that you
either don't tolerate Dairy don't have
access to raw dairy or just want to
consume the supplement where do we get
it from so the two companies that we use
right now in our practice and again no
relationship with these companies but
that's allergy research group or ARG and
gerro both of these companies have a
product that is the lacto faren um the
ARG group uses a K in it just to make it
look different and has a reasonably high
dose and jro has a a similar product
their doses are around 250 350 milligram
something like that in each of us
serving and then if you look at the
study that 225 MGS in the Rabon nucleus
enriched Lao lactoferrin if you do the
math on which of the products is heavier
and there and what's the combination
it's likely to be about 200 Mig of
lactoferrin so somewhere between that
200 300 400 milligram seems to be what
the researchers were thinking would
should be studied if you think about how
much is in raw milk this gets a little
bit super physiologic though because in
raw milk there's about 20 to 25
milligrams per cup of milk so to get to
200 to 300 or 400 you know milligrams of
lactoferrin you're talking about 10 20
30 cups of milk which is obviously a lot
of milk
so I also wanted to say this one thing
which is that some of these products
like ARG and gerro I think both of them
are available on Amazon I strongly
discourage people from buying
supplements on Amazon or from big box
stores because there have been multiple
studies showing how the things that are
in the bottle are not necessarily what's
supposed to be in the bottle and also
there's no guarantee that those have
been stored appropriately in a
temperature controlled Warehouse how
long have they been there what is the
you know the true expiration date Etc so
strongly encourage people to buy
products from companies like full script
which is an online dispensary that a lot
of doctors will use we use it in our
practice as well if you don't have
access to full script by any of the
doctors that you know and you want to
have access to our full script without
being a patient consider joining our
health span nation which is our
membership Community where people are
upleveling each other visiting us once a
week for a live Q&A with myself or a
team member and they have access to both
our full script which has a lot of these
products in it but also so to other
discounts that we give to our members
and patients the cost of or the cost
difference in those discounts can offset
the cost of the membership in a second
so something to consider and you can
check out links for that in the
description or go to our website optimal
human health.com and you can find that
there so this was a review of lacto
Farin and if you like this consider this
video the three best supplements to
build bone health or this video the best
supplements for building muscle mass all
of them obviously on supplements so
remember that osteoporosis isn't the end
but deciding to reverse it is a
beginning