Shift Immune Cells From Attack to Brain-Defense Mode | David Perlmutter MD|Vital Signs

Shift Immune Cells From Attack to Brain-Defense Mode | David Perlmutter MD|Vital Signs

seevitalsigns
seevitalsigns
Sep 3, 2026

By 2060, it’s predicted that 1 million U.S. adults will develop dementia each year, compared with half that number in 2020. Leading neurologist Dr. David Perlmutter MD says it’s what people in their 30s and 40s do now that can lower their risk of developing dementia decades later.

On “Vital Signs,” the best-selling author and fellow of the American College of Nutrition highlighted “upstream” causes of Alzheimer’s disease and steps to be taken decades before to avoid germinating the seeds of the condition.

“We know that when our blood sugar elevates, it tends to change our brain’s immune system away from being supportive and loving … to being destructive,” said Perlmutter, referring to the microglia—the main cells of the immune system.

The bestselling author of “Drop Acid” and other titles, Perlmutter has garnered millions of views on YouTube, emphasizing the metabolic and dietary connections to brain health.

“If you keep your body’s metabolism in shape, keep your insulin level low, keep your blood sugar low … your microglia are going to be happy, supportive, and you’re going to help reduce your risk for brain degeneration.”

How do we enhance diet and lifestyle to lower blood sugar and support brain health?

What steps do we take now to detect and lower brain disease risk years before symptoms are likely to appear?

“As it relates to the brain and the brain’s degenerative conditions like Alzheimer’s …. we can be the architects of our brains’ destiny if we make the changes now,” says Perlmutter.

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Vital Signs’ host, guests, and contributors offer general information on improving health and wellness. This is not intended as diagnosis or medical advice. You should consult your medical doctor or holistic doctor before enacting any suggested strategies for health and wellness improvement, including those in relation to preventing or treating specific diseases featured on this program.