Immune Thrombocytopenic Purpura (ITP) - Causes, Pathogenesis, Signs & Symptoms, Diagnosis, Treatment

Immune thrombocytopenic purpura, or ITP, is a syndrome characterized by formation of autoantibodies against a person’s own platelets, leading to their destruction in the spleen via phagocytosis, which ultimately results in reduced numbers of platelets in the circulation and subsequent clinical manifestations.
The disease commonly occurs in children as acute ITP, usually following a viral infection.
In addition, certain medications and vaccines can also trigger this condition.
In adults, most cases of ITP are chronic, and occur in middle-aged women.

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