Endocannabinoids and Mental Health

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Endocannabinoids and Mental Health
#CBD #Mentalhealth #cannabis
Dr. Dawn-Elise Snipes


Objectives
~ Explore the role of the endocannabinoid system in
~ Mood disorders
~ Cognitive disorders
~ Autoimmune and inflammatory disorders
~ Pain
~ Stress

Intro
~ The eCB system targets both monoamines and the HPA axis, which is also dysregulated during stress-induced psychiatric disorders
~ Hyperactivity of endocannabinoid signaling contributes to excessive intake and storage of high-calorie foods, while endocannabinoid hypoactivity is a risk factor for the development of depression, anxiety and post-traumatic stress disorder
~ The ECS is comprised of endogenous cannabinoids (endocannabinoids), cannabinoid receptors, and the enzymes responsible for the synthesis and degradation of endocannabinoids
~ Endogenous cannabinoids are endogenous lipids that engage cannabinoid receptors
~ The first discovered and best-characterized endocannabinoids are anandamide (arachidonoyl ethanolamide) and 2-arachidonoyl glycerol (2-AG)
~ Both 2 AG and anandamide are agonists for CB1 and CB2 receptors
~ In systems with low receptor expression, anandamide can antagonize the effects of more efficacious agonists
~ On demand, endocannabinoids are liberated in and released into the extracellular space. This contrasts with classical neurotransmitters that are synthesized ahead of time and stored in synaptic vesicles
~ CB1 receptors are abundant in the central nervous system (CNS), particularly in cortex, basal ganglia, hippocampus, and cerebellum
~ CB2 receptors are expressed at much lower levels in the CNS
~ Physical exercise mobilizes endocannabinoids