The , commissioner of the U.S. Food and Drug Administration, on May 12, 2026, brought to the forefront a heated controversy over fruit-flavored nicotine vapes.
Rumors had been circulating for weeks that , in large part due to Makary’s disagreement with Trump over the . Makary reportedly disagreed in private with the FDA’s decision, which came soon after Trump pushed the FDA to move more quickly in approving fruit-flavored vapes.
Before , the agency had only approved . The clash between Trump and Makary over whether to allow fruit-flavored vapes is a high-profile example of the .
Beyond Washington, the public health community is also divided. Researchers are working to understand how flavored vapes affect public health, but the evidence is complicated.
We are a team of public health researchers who study , and as it relates to tobacco and nicotine products. Our team at the at the University of Michigan and University of Massachusetts Amherst is studying questions about flavors in these products.
The authorization of two fruit-flavored vapes marks a pivotal moment in U.S. e-cigarette regulation.
FDA’s role in regulating tobacco and nicotine
The , which was signed into law in 2009, gave the FDA the authority to regulate the manufacture, distribution and marketing of tobacco products. This includes nicotine alternatives such as e-cigarettes, vapes and oral nicotine pouches.
Tobacco and nicotine products, such as major cigarette brands, that were on the market before 2007 , but new products, like vapes, do. To be authorized, new tobacco and nicotine products must meet the standard of being . In other words, their benefits to the population as a whole must be judged to outweigh their risks.
The at the FDA is responsible for making these decisions and implementing regulations. Academic research centers, like ours, support the center in understanding how its policies might affect public health.
Vaping has a lower relative risk than smoking
Vaping nicotine is not risk-free, but research is clear that . Vapes and e-cigarettes don’t contain tobacco leaf like cigarettes do, nor do they have that are found in cigarettes. Smoking involves burning organic material, which releases cancer-causing pollutants; vaping does not.
Vapes can contain potentially harmful chemicals, but these are usually in much lower amounts than those found in cigarettes. Nicotine is an addictive chemical, but it . The FDA’s regulation and oversight of vapes is important for public safety. As of May 2026, the FDA has approved 45 vaping products that
On the other hand, the U.S. is , including colorful devices manufactured in China. It can be difficult to know what is in illegal vapes.
Because vaping is not risk-free but has a lower relative risk than smoking, it presents an increased risk for people who do not otherwise use tobacco or smoke, but a .
Flavored vapes attract new users, especially youth
Flavored vapes can include menthol and mint, fruit and sweet flavors and concept flavors with names like “jazz,” “solar,” “fusion” and “unicorn puke.” Other flavored vapes are often packaged in bright and appealing colors, even if they do not include explicit flavor description words.
The recent FDA decision to approve two fruit- and sweet-flavored nicotine vapes, which have the color-coded names of “Sapphire” and “Gold,” is a potentially significant expansion of the FDA’s approach to authorizing e-cigarettes.
Research shows that , including young people who do not have a history of smoking tobacco. It also shows that experimenting with flavors increases the appeal of vapes among adolescents. Young people often think fruit-flavored vapes are less harmful than tobacco-flavored vapes.
Flavored vapes might help people quit smoking
Flavored vapes can attract youth, but they can also appeal to people who smoke. For people who smoke, switching to nicotine vapes can and potentially lower their likelihood of tobacco-related disease.
Researchers regularly assess the scientific evidence on whether e-cigarettes can help people stop smoking. Regularly updated evidence across more than a hundred studies continues to show that nicotine vapes can .
However, researchers don’t yet know whether or how adding flavors to vapes might affect smoking and vaping. While fruity and sweet flavors can be , tobacco and menthol flavors are sometimes more popular among older people who have a history of smoking tobacco.
As the recent clash between Trump and Makary shows, the debate over flavored vapes continues. Whatever the outcome, it remains important that decisions made about vapes are based on scientific evidence, and that the reasons behind policy decisions are communicated effectively to the public.
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