Currently, the hantavirus epidemic is attracting global attention.
But do you know? The Chinese Communist Party had already announced with great fanfare in March this year that they had successfully developed a hantavirus vaccine!
On March 30, the official WeChat public account of China’s “virology community” published an article titled, “The Zhang Fanglin/Ye Wei Team at Air Force Medical University Successfully Develops a Hantavirus Nucleic Acid Vaccine Based on Prefusion Conformation Stabilization.”
The article states that recently, the Zhang Fanglin/Ye Wei team from the Department of Microbiology, School of Basic Medical Sciences, Air Force Medical University, successfully developed a hantavirus nucleic acid vaccine based on prefusion conformation stabilization.
This study used structural vaccinology principles to design and verify the prefusion conformation-stabilized hantavirus glycoprotein (GP) immunogen, combined with DNA and mRNA-LNP nucleic acid vaccine platforms, achieving strong and long-lasting immune protection against hantavirus.
At the same time, it provided the optimal heterologous booster program for people who had received inactivated vaccines, laying a key foundation for the research and development of the next generation of hantavirus vaccines.
The article claims that this study is the first to apply the structure-guided prefusion conformation stabilization strategy to hantavirus vaccine development, and verifies that the prefusion-stabilized GP-C3 antigen, delivered via DNA or mRNA-LNP platforms, can strongly activate germinal center responses, induce high-titer, long-lasting, and broad-spectrum neutralizing antibody responses, and also provide the optimal heterologous booster program for inactivated vaccine-immunized populations.
At the end of the article, it mentions that Zhang Fanglin, Xu Zhikai, Lei Yingfeng, and Ye Wei from the School of Basic Medical Sciences, Air Force Medical University, are the co-corresponding authors of this paper. Ye Wei, Dang Yamei, Wang Yuan, Yang Qiqi, Zhang Hui, physician Ye Chuantao from Tangdu Hospital, and Wei Jing from Shaanxi Provincial CDC are the co-first authors of this paper.
This research received funding from projects such as the National Key Research and Development Program and the National Natural Science Foundation of China.
This article was published only a little over ten days ago, and then a hantavirus outbreak occurred on the Atlantic cruise ship!
These two are screenshots of this article.
