Preclinical findings highlight biological activity of plant compounds, though human trials are still needed.
By yourNEWS Media Newsroom
Lemongrass, a plant widely used in culinary and traditional medicine practices, is being examined in scientific research for potential anti-cancer properties, with studies focusing on its active compounds and their effects on cancer cells in laboratory and animal models.
Researchers have identified citral, a primary compound in lemongrass, along with other components such as geraniol and nerol, as contributors to its biological activity. Preclinical studies indicate that these compounds may influence cancer cell behavior through multiple mechanisms, including the induction of apoptosis, or programmed cell death.
Laboratory research has shown that lemongrass extracts can trigger oxidative stress within cancer cells, disrupt mitochondrial function, and activate cellular pathways associated with cell death. Additional findings suggest that citral may interfere with cell division by inhibiting tubulin polymerization, a process necessary for cancer cells to replicate.
Some studies have also examined the compound’s interaction with enzymes linked to cancer progression. Research indicates citral may inhibit ALDH1A3, an enzyme associated with cancer stem cell activity and resistance to certain treatments, though these findings remain limited to preclinical settings.
Animal studies have produced notable results. In one experiment involving mice implanted with human non-Hodgkin’s lymphoma cells, oral administration of lemongrass extract was associated with a reported reduction in tumor volume over a short period, without observed weight loss or toxicity in the animals. Other studies have reported slowed tumor growth in colon cancer models and reduced tumor development in genetically predisposed animals.
In vitro research has demonstrated dose-dependent effects across several cancer cell lines, including colon, breast, liver, lung, and blood cancers. Researchers have also noted indications that lemongrass compounds may affect cancer cells differently than healthy cells, though this selectivity has not been confirmed in human studies.
The plant has a long history of use in traditional medicine systems, including Ayurveda and Traditional Chinese Medicine, where it has been used for digestive issues, fever, and general wellness. This historical use has contributed to its continued scientific evaluation.
Despite the findings, scientists emphasize that the research remains in early stages. Most evidence comes from laboratory and animal studies, and clinical trials involving human participants are needed to determine safety, effectiveness, and appropriate dosing.
Researchers also note challenges related to bioavailability, as compounds such as citral can degrade quickly and may not be easily absorbed by the body. Efforts are underway to develop more stable delivery methods to support further investigation.
Health experts caution that while lemongrass can be safely consumed as part of a normal diet—such as in teas, soups, and other foods—it should not be considered a treatment for cancer. The use of concentrated extracts or supplements for medical purposes should only occur under professional guidance.
The current body of research highlights lemongrass as a subject of ongoing scientific interest, with studies continuing to explore its potential role within broader investigations into plant-based compounds and human health.
Source: Natural News